*Disclaimer* For the sake of isolating Drugs and Alcohol, I have omitted any movies that could be included in the list, but were more about the comedy than the drugs. That's not to say these movies aren't at all funny, they just weren't comedies per say.
In the 1960s, a young man named George Jung from a working class Massachusetts suburb, moves to California in search of the "American Dream." He travels to Venice Beach where he meets a marijuana dealer, Derek Foreal. He starts enjoying the lucrative bliss of selling marijuana but soon finds himself in prison, where he develops connections to the Colombian cocaine cartels. Once released from jail, he quickly rises to the top by single-handedly becoming the world's premiere importer of cocaine to the U.S., before his empire comes crashing down on him.
4.) Pain and Gain
Based on a real life story that took place in Miami during the late 1990s, Donald Lugo and Paul Doyle are two successful, yet cash strapped body builders who want to get out of the grind and get the wealth they feel they deserve. Doyle is a born again fundamentalist Christian who just got out of serving 10 years in prison. As good as he is at body building, he's sexually frustrated as years of doing hardcore steroids in prison have really taken a toll on his body and his manhood. Lugo is employed as a trainer and consultant at the gym that they belong to and wants to be the most successful person he can be with the help of a sleazy motivational speaker, he aims for the top. Then enters Victor Kershaw - a Colombian immigrant and semi wealthy restaurant franchise owner who joins the gym. The manically picky Kershaw begins to taunt every aspect of the workout he's being provided with. Eventually Doyle and Lugo decide that they've had enough of his madness. The two kidnap and torture Kershaw for a month to gain access to his fortune, which sets a chain reaction of bad events.
3.) Wolf of Wall Street
In the early 1990s, Jordan Belfort teamed with his partner Donny Azoff and started brokerage firm Stratford-Oakmont. Their company quickly grows from a staff of 20 to a staff of 250 and their status in the trading community and Wall Street grows exponentially. So much that companies file their initial public offerings through them. As their status grows, so do the amount of substances they abuse and their lies. They draw attention like no other, throwing lavish parties for their staff when they hit the jackpot on high trades. That ultimately leads to Belfort featured on the cover of Forbes Magazine, being called "The Wolf Of Wall St.".
Tony Montana, a Cuban immigrant, and his friend Manolo "Manny" Ray, build a drug empire in Miami in the early 1980s. The story follows Montana's career in the cocaine distribution industry and the events that ultimately lead to his downfall
1.) Requiem For a Dream
This film parallels the lives of four interrelated people living in Brighton Beach, whose recreational drug use soon turns to addiction. The movie follows Sara Goldfarb, a lonely, TV obsessed widow, her son Harry, his drug dealer buddy Tyrone, and Harry's girlfriend Marion . This movie examines the direct and indirect results of drug use, as you watch the addicts on their respective downward spirals.